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Biotin-OXM(1-37)
The native form of GLP-1 in humans is the GLP-1 (7-36) amide. GLP-1 (7-36) amide is highly unstable (half-life <-2 minutes) due to proteolytic degradation by the serine protease, dipeptidyl peptidase-IV (DPP-IV). DPP-IV cleaves the N-terminal histidine and alanine residues from GLP-1 to generate two equipotent forms: GLP-1 (9-37) and GLP-1 (9-36) amide. This degradation mitigates against the therapeutic use of GLP-1 itself, therefore DPP-IV-resistant peptide analogues have been developed and licensed for clinical use. Contains an N-terminal biotin tag for easy detection and purification.
| Chemical | |
|---|---|
| CAS # | 106612-94-6 |
| Form | Lyophilized |
| Molecular Formula | C151H228N40O47 |
| Molecular Weight | 3524 |
| Purity | >95% by HPLC |
| Reconstitution | Reconstitute with PBS or H20 to desired concentration. Due to the nature of this peptide, it is recommended to first mix with 10 ul of DMSO. |
| Sequence | Biotin-HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH2 |
| Shipping and Handling | |
| Storage Condition | Store at -20°C |
