Human dermal fibroblasts (HDFs) play a pivotal role in the development, structure, and repair of the skin. They are key components of the extracellular matrix (ECM), producing and maintaining collagen, elastin, and other structural proteins that provide mechanical support and elasticity to the skin. HDFn, which are obtained from the skin of newborns, is often preferred in research due to their proliferative potential and the ability to more closely mimic the behavior of fibroblasts during skin development and wound healing. In addition, they secrete large quantities of hyaluronan in response to inflammatory stimuli.

Human neonatal dermal fibroblasts were cryopreserved at the end of the primary culture. Normal Human Epidermal Keratinocytes (Cat# TDC-P1202) from matched donors are available for certain lots.

TDC-P1201-product-datasheet-HDFn.pdf